Health
CEPI, partners conducting clinical studies to develop vaccine for Lassa Fever
The Coalition for Epidemic Preparedness Innovations (CEPI), says studies are underway to conduct clinical trials to develop a vaccine for Lassa fever in West Africa.
Dr Elsie Ilori, the coalition’s National Project Coordinator for Enable 1.5 in Nigeria disclosed this on Monday in Abuja at the linauguration of the project.
It will be recalled that Lassa fever is a deadly hemorrhagic fever prevalent in West Africa.
According to Ilori, the main purpose of the trials is for clinical studies to be able to produce vaccine towards Lassa fever disease, to ensure that the burden of the disease in the country and the West Africa region is reduced.
“The study will help us understand Lassa fever itself, how people react to the disease, and the effects of the vaccine on people.
“By understanding the disease, we will be able to understand how the vaccine will work with people.”
She also said that the study aimed to understand Lassa fever’s symptoms and effects on people, evaluate the vaccine’s safety, tolerability, and immunogenicity, and develop a vaccine effective against multiple strains of the disease.
“We are working closely with community leaders, healthcare workers, and local authorities to sensitise the public about the study.
“This includes explaining the study’s objectives, benefits, and potential risks.”
She said that three countries, Nigeria, Sierra Leone, and Liberia were participating, with five sites selected based on high Lassa fever burden.
However, Nigeria has three sites: Federal Medical Centre, Owo, Irrua Specialist Teaching Hospital, Edo state and Alex Ekwueme University Teaching Hospital, Abakaliki.
“These sites were selected due to their high disease burden, increasing the likelihood of enrolling participants with Lassa fever,” Ilori added.
She said that the study prioritised community engagement and sensitisation, whereby researchers would conduct house-to-house enrollment, obtaining consent from household heads.
She also added that participants must provide informed consent and could withdraw at any time without consequences.
She further said that the study would help sensitise people and prepare them for vaccine acceptance.
“The study’s success relies on collaboration between researchers, healthcare workers, and community leaders from Nigeria, Sierra Leone, and Liberia.
“We believe that this study will pave the way for a vaccine, bringing relief to communities ravaged by the disease.
“We are one step closer to a vaccine, and that’s a remarkable achievement.
“The study’s findings is expected to also inform public health policy and guide future vaccine development.”
In addition to CEPI, the study is supported by global health partners, including the World Health Organisation and the Federal Government.
Royce Fulton, the Programme Manager, CEPI for the Enable Lassa Research Programme, said that beyond developing the vaccines through clinical trials, it was important to also be able to identify where the disease was.
Also, to build the necessary capacities within the countries and within the partners in Nigeria and other countries in order to be able to really prepare for the great work that lay ahead.
According to him, having clinical trials at a large scale that allow for the identification of the effectiveness of a new vaccine will be with the ambition of having the vaccine ready by 2030 in Nigeria.
“So this Enable 1.5 study, what is going to be the methodology, the outcomes, and when is it possible to be ready? We’re thinking that for the vaccine trials, these are going to be happening imminently.
“We do feel that there is a lot yet to be done for preparedness, for readiness, to make sure the sites and the countries are really equipped with the knowledge, expertise and the tools to be able to conduct large-scale clinical trials.
“So what we have done is spent the past five years implementing a large multi-center prospective cohort trial in order to be able to understand where the disease lies by following 23,000 subjects in the past few years.
“To understand how many of them developed Lassa fever in that time, how many of them are exposed to the vector, which is the rats that live in the houses with them.
“Also, how many of these people can be pulled into further research to help us understand just how effective this vaccine is going to be.
The reports have it that participants from Nigeria, Liberia, and Sierra Leone will be enrolled with selection criteria based on age, with adults, adolescents, and children as young as two years old being eligible, as well as people living with HIV.
The aim of the study is to strengthen country clinical trial capacity for late stage vaccine trials and develop scientific data to guide vaccine development. (NAN) (www.nanews.ng)
Health
New Malaria Plan Puts States, Local Data At Centre Of Nigeria’s 2030 Response
Cyril Ogar
Nigeria’s latest malaria data point to a country making progress overall but facing sharply different disease burdens from one state to another, prompting health authorities to shift emphasis towards locally tailored interventions under a new five-year strategy.
The National Malaria Strategic Plan (NMSP) 2026–2030, launched alongside the 2025 Nigeria Malaria Indicator Survey (NMIS) report, seeks to cut malaria parasite prevalence and deaths by 50 per cent from 2025 levels by 2030.
Rather than applying a uniform national response, the plan prioritises interventions based on local epidemiological evidence, while also calling for stronger domestic financing, improved diagnosis and treatment, better surveillance and clearer accountability.
The Coordinating Minister of Health and Social Welfare, Prof. Muhammad Ali Pate, represented by the ministry’s Permanent Secretary, Mrs Daju Kachallom, presented the government’s position at the joint launch in Abuja.
Pate described the survey and strategic plan as essential tools for identifying weaknesses in malaria control and directing resources towards areas with the greatest need.
He said the survey’s findings on prevalence, prevention, diagnosis and treatment would support policy development, programme implementation, resource allocation and performance assessment.
The minister said the strategic plan was designed to accelerate progress towards a malaria-free Nigeria while remaining consistent with national health priorities and the World Health Organisation’s global malaria strategy.
He commended the National Malaria Elimination Programme (NMEP), the National Population Commission (NPC), development partners and other stakeholders involved in producing the survey and plan.
Pate also called for a shared national effort involving federal and state governments, the private sector, communities and households, stressing that malaria elimination could not be achieved by government alone.
The 2025 NMIS shows that malaria parasite prevalence among children aged six to 59 months, measured through microscopy, fell from 42 per cent in 2010 to 23 per cent in 2018, 22 per cent in 2021 and 15 per cent in 2025.
However, the national improvement masks substantial differences between states. Prevalence among children in the same age group ranged from two per cent in Lagos State to 31 per cent in Ebonyi State.
The figures indicate that progress has not been evenly distributed and that malaria control efforts must be adapted to the conditions in individual states and communities.
Earlier, the National Coordinator of NMEP, Dr Nnenna Ogbulafor, said the NMSP was developed from the 2025 NMIS findings and other programme data.
She said the evidence would help policymakers locate high-burden areas, improve the design of interventions and direct limited resources to communities most in need.
Ogbulafor said the plan was aligned with Nigeria’s health sector priorities and the WHO Global Technical Strategy for Malaria 2016–2030.
She identified policy alignment, state-level leadership, domestic financing, partnerships and accountability as central to implementation.
The national coordinator urged state governments, civil society organisations and development partners to take ownership of the plan and support coordinated, adequately funded malaria programmes.
She said the differences in prevalence across states made subnational planning indispensable to meeting the national targets.
Ogbulafor called on states to develop comprehensive malaria control programmes reflecting local disease burdens, epidemiological evidence and available resources.
She also stressed the need for sustained domestic financing and partnerships to close funding gaps and maintain implementation through 2030.
NMEP, she said, would work with the National Malaria Working Group and international partners to track implementation, assess performance and review results regularly.
The plan aims to raise access to and use of preventive interventions to at least 80 per cent, achieve at least 90 per cent effective coverage of malaria diagnosis and appropriate treatment among at-risk populations, and improve surveillance performance from a baseline of 47 per cent to 70 per cent by 2030.
It also targets stronger governance and organisational capacity, with at least 60 per cent of malaria programme resources expected to come from domestic sources by 2030.
The survey data show that prevention remains uneven. Only 54 per cent of households had at least one insecticide-treated net, while 45 per cent of children under five and 54 per cent of pregnant women aged 15–49 slept under a net on the night before the survey.
Protection during pregnancy was also incomplete. Among women aged 15–49 who had a live birth in the preceding two years, 62 per cent received at least one dose of sulphadoxine-pyrimethamine during their last pregnancy, but only 33 per cent received three or more doses.
The findings point to the need to expand access to insecticide-treated nets and intermittent preventive treatment for pregnant women.
Diagnosis is another major gap. Of children under five who had a fever in the two weeks before the survey, 59 per cent had advice or treatment sought, but only 18 per cent had blood taken for malaria testing.
The strategic plan therefore places emphasis on prompt testing, appropriate treatment, preventive services and public awareness.
In his remarks, the Director-General of NPC, Dr Abubakar Muhammed, pledged the commission’s continued support for credible demographic and health data to guide policymaking and malaria elimination efforts.
Muhammed said the survey reflected the partnership between the Federal Ministry of Health and Social Welfare, through NMEP, and the NPC.
He said the collaboration brought together expertise in malaria control, demographic surveys and data management to produce information for national planning and development.
The NPC director-general said the commission would continue to modernise its survey operations through technologies such as the Global Positioning System (GPS) and spatial techniques.
He urged policymakers, programme managers, researchers and development partners to use the findings to refine strategies, improve implementation and target communities where interventions were most needed.
Muhammed commended the ministry, NMEP, technical consultants, state enumerators and field teams for their roles in conducting the survey.
He said the report would provide a strong evidence base for a coordinated national malaria response.
The launch of the NMIS report and NMSP 2026–2030 places the next phase of Nigeria’s malaria response on a clearer understanding of where the disease remains most entrenched, while challenging states and partners to convert that evidence into measurable local action.
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