Foreign news
Sinovac launches Phase 3 trial for COVID-19 vaccine in Indonesia, reports Phase 2 details
China’s Sinovac Biotech Ltd launched a late-stage human trial on Tuesday that will involve as many as 1,620 patients in Indonesia for a COVID-19 vaccine candidate that it is developing with Indonesian state-owned peer Bio Farma.
Sinovac is testing its vaccine abroad because there are too few new infection cases in China, making it no longer a satisfactory site for late-stage trials.
Separately, Sinovac released details on Monday from a mid-stage, or Phase 2, study in which it said the vaccine candidate appeared to be safe and induced detectable antibody-based immune responses in subjects.
The candidate, known as CoronaVac, is among a few potential vaccines that have entered late-stage trials for a large-scale study to gather proof of efficacy for regulatory approval.
CoronaVac is already undergoing a late-stage trial in Brazil and Sinovac expects to also test it in Bangladesh.
Sinovac’s Indonesia trial comes as Southeast Asia’s most populous country grapples with spiking infection numbers, with over 127,000 cases recorded as of Tuesday. The trial has so far recruited 1,215 people and will last six months.
“The threat of COVID-19 will not subside until a vaccine is given to all the people,” said Indonesian President Joko Widodo at a ceremony to launch the trial in Bandung, West Java. “Hopefully in January, we can produce and vaccinate everyone in the country.”
In addition to Bio Farma and Sinovac, private Indonesian firm Kalbe Farma and South Korea’s Genexine are cooperating to produce a separate vaccine. It is yet unclear how many doses these partnerships will produce and by when.
In Sinovac’s mid-stage trial involving 600 participants in China, the rate of fever in patients was relatively lower than other COVID-19 candidates including one from AstraZeneca, the study showed ahead of peer review.
Mid-stage trials usually test a candidate’s safety and ability to trigger an immune response in a relatively small number of people before it enters late-stage tests.
The study noted that the process to make the vaccines used in the Phase 2 trial was more optimized than in Phase 1, which produced more immunogens and triggered better immune responses.
Vaccines used in the late-stage trials will be made using the optimized process, a Sinovac spokesman said.
The Phase 2 results only included antibody-based immunity, the researchers said, adding that the candidate was being evaluated for other important components of the immune system
Foreign news
EU Cautiously optimistic on Syria engagement – Official
Irish foreign minister Simon Harris said on Monday that the European Union (EU) “is cautiously optimistic on Syria engagement” but called for more deeper engagement to strengthen relations with the country.
Harris said this at a news conference held at the EU Headquarters in Brussels, the Belgian capital.
“It’s early days, but I think there are signs of optimism. But it is important that we continue to engage.
“I don’t think it would be a good scenario if any other geopolitical actors and forces engage with Syria and for the European Union not to be in a position to intensively engage with them,“ he said.
In her remarks, Ms. Kaja Kallas, the Vice-President of the EU described Syria’s future as fragile but said that the bloc needed to take the right steps.
“But of course, we need to see the right steps as well. Right now, they’re saying all the right words, and they are doing also the right things.
“Therefore, we have this set step-for-step approach, and if they take the steps, then we are willing to take the steps as well,’’ she said.
On the war in Gaza, Harris said President Donald Trump and his team are very much a party to the ceasefire deal between Israel and Hamas after the intensive work that was put in.
He conceded that the Trump administration put in a lot of effort to arrive at a ceasefire agreement in the days before his assumption of office for a return to the White House.
“I think that was important and there is no doubt that the intensive work invested by the Trump administration played a very significant role in helping to bring about a ceasefire – a ceasefire that has now seen a cessation of hostilities, the killing, and the bombings.
“Also, that has seen the flow and has seen hostages being released. It’s really important that the ceasefire is in place.
“It is also important, though, to acknowledge in that ceasefire agreement itself, it does talk about people being able to return, and therefore, I think it’s important that we’re consistent in the approach that we take.
“The priority, I think, needs to be on implementing to the letter, the ceasefire agreement.”
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